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1

The synthesis of pentaprismane

Philip E. Eaton, Yat Sun Or, Stephen J. Branca, B.K. Ravi Shankar

Journal:

Year:

1986

Language:

english

File:

PDF, 1.39 MB

english, 1986

2

Synthesis and Antimicrobial Activity of 4 H -4-Oxoquinolizine Derivatives: Consequences of Structural Modification at the C-8 Position

Ma, Zhenkun, Chu, Daniel T. W., Cooper, Curt S., Li, Qun, Fung, Anthony K. L., Wang, Sanyi, Shen, Linus L., Flamm, Robert K., Nilius, Angela M., Alder, Jeffery D., Meulbroek, Jonathan A., Or, Yat Sun

Journal:

Journal of Medicinal Chemistry

Year:

1999

Language:

english

File:

PDF, 221 KB

english, 1999

3

ChemInform Abstract: Synthesis of 2-Fluoro-6-O-propargyl-11,12-carbamate Ketolides. A Novel Class of Antibiotics.

Ly T. Phan, Richard F. Clark, Michael Rupp, Yat Sun Or, Daniel T. W. Chu, Zhenkun Ma

Journal:

Year:

2001

File:

PDF, 33 KB

2001

4

Synthesis of Novel 6,11-O-Bridged Bicyclic Ketolides via a Palladium-Catalyzed Bis-allylation.

Guoqiang Wang, Deqiang Niu, Yao-Ling Qiu, Ly Tam Phan, Zhigang Chen, Alexander Polemeropoulos, Yat Sun Or

Journal:

Year:

2005

File:

PDF, 13 KB

2005

5

Selective epimerization and skeletal resection in the ascomycin framework: A study of the biological consequences of lactam rotamer selection

Rolf Wagner, Teresa A. Rhoades, Yat Sun Or, Benjamin C. Lane, Jay R. Luly

Journal:

Year:

1996

Language:

english

File:

PDF, 618 KB

english, 1996

6

Synthesis of novel 4′-substituted 16-membered ring macrolide antibiotics derived from leucomycins

Zhaolin Wang, Tianying Jian, Ly T. Phan, Yat Sun Or

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 141 KB

english, 2004

7

Design, synthesis, and antibacterial activities of novel 3,6-bicyclolide oximes: Length optimization and zero carbon linker oximes

Datong Tang, Yonghua Gai, Alexander Polemeropoulos, Zhigang Chen, Zhe Wang, Yat Sun Or

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2008

Language:

english

File:

PDF, 220 KB

english, 2008

8

Synthesis of 3,6-bicyclolides: A novel class of macrolide antibiotics

Yonghua Gai, Datong Tang, Guoyou Xu, Zhigang Chen, Alexander Polemeropoulos, Zhe Wang, Yat Sun Or

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2008

Language:

english

File:

PDF, 269 KB

english, 2008

9

The chemistry of ascomycin: Structure determination and synthesis of pyrazole analogues

Yat Sun Or, Richard F. Clark, Qinghua Xie, James McAlpine, David N. Whittern, Rodger Henry, Jay R. Luly

Journal:

Year:

1993

Language:

english

File:

PDF, 1.04 MB

english, 1993

10

Synthesis and antibacterial activity of novel 6-O-substituted erythromycin A derivatives

Richard F Clark, Zhenkun Ma, Sanyi Wang, George Griesgraber, Michael Tufano, Hong Yong, Leping Li, Xiaolin Zhang, Angela M Nilius, Daniel T.W Chu, Yat Sun Or

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2000

Language:

english

File:

PDF, 173 KB

english, 2000

11

Novel 3-deoxy-3-descladinosyl-6-O-methyl erythromycin a analogues. Synthesis and in vitro activity

Richard L. Elliott, Daisy Pireh, Angela M. Nilius, Pauline M. Johnson, Robert K. Flamm, Daniel T.W. Chu, Jacob J. Plattner, Yat Sun Or

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1997

Language:

english

File:

PDF, 307 KB

english, 1997

12

Pentaprismane

Eaton, Philip E., Or, Yat Sun, Branca, Stephen J.

Journal:

Journal of the American Chemical Society

Year:

1981

Language:

english

File:

PDF, 380 KB

english, 1981

13

Design, Synthesis, and Antimicrobial Activity of 6-O-Substituted Ketolides Active against Resistant Respiratory Tract Pathogens

Or, Yat Sun, Clark, Richard F., Wang, Sanyi, Chu, Daniel T. W., Nilius, Angela M., Flamm, Robert K., Mitten, Michael, Ewing, Patty, Alder, Jeff, Ma, Zhenkun

Journal:

Journal of Medicinal Chemistry

Year:

2000

Language:

english

File:

PDF, 88 KB

english, 2000

14

Opsin pigments formed with acyclic retinal analogues: Minimum ‘ring portion’ requirements for opsin pigment formation

Rosalie Crouch, Yat Sun Or

Journal:

Year:

1983

Language:

english

File:

PDF, 316 KB

english, 1983

15

Anhydrolide Macrolides. 2. Synthesis and Antibacterial Activity of 2,3-Anhydro-6- O -methyl 11,12-Carbazate Erythromycin A Analogues

Griesgraber, George, Kramer, Mark J., Elliott, Richard L., Nilius, Angela M., Ewing, Patty J., Raney, Patti M., Bui, Mai-Ha, Flamm, Robert K., Chu, Daniel T. W., Plattner, Jacob J., Or, Yat Sun

Journal:

Journal of Medicinal Chemistry

Year:

1998

Language:

english

File:

PDF, 185 KB

english, 1998

16

Studies on the synthesis of the antitumor agent CC-1065. Synthesis of the unprotected cyclopropapyrroloindole A portion using the 3,3'-bipyrrole strategy

Magnus, Philip, Gallagher, Timothy, Schultz, James, Or, Yat Sun, Ananthanarayan, T. P.

Journal:

Journal of the American Chemical Society

Year:

1987

Language:

english

File:

PDF, 808 KB

english, 1987

17

Synthesis of New 14-Membered Macrolide Antibiotics via a Novel Ring Contraction Metathesis

Lazarova, Tsvetelina I., Binet, Sophie M., Vo, Nha H., Chen, Jason S., Phan, Ly T., Or, Yat Sun

Journal:

Organic Letters

Year:

2003

Language:

english

File:

PDF, 52 KB

english, 2003

18

Synthesis and Antibacterial Activity of a Novel Class of 4‘-Substituted 16-Membered Ring Macrolides Derived from Tylosin

Phan, Ly T., Jian, Tianying, Chen, Zhigang, Qiu, Yao-Ling, Wang, Zhaolin, Beach, Theresa, Polemeropoulos, Alex, Or, Yat Sun

Journal:

Journal of Medicinal Chemistry

Year:

2004

Language:

english

File:

PDF, 68 KB

english, 2004

19

Structure-function studies in a series of carboxyl-terminal octapeptide analogs of anaphylatoxin C5a

Kawai, Megumi, Quincy, David A., Lane, Benjamin, Mollison, Karl W., Or, Yat Sun, Luly, Jay R., Carter, George W.

Journal:

Journal of Medicinal Chemistry

Year:

1992

Language:

english

File:

PDF, 552 KB

english, 1992

20

Synthesis of Novel 6,11-O-Bridged Bicyclic Ketolides via a Palladium-Catalyzed Bis-allylation

Wang, Guoqiang, Niu, Deqiang, Qiu, Yao-Ling, Phan, Ly Tam, Chen, Zhigang, Polemeropoulos, Alexander, Or, Yat Sun

Journal:

Organic Letters

Year:

2004

Language:

english

File:

PDF, 113 KB

english, 2004

21

Small peptide inhibitors of smooth muscle myosin light chain kinase

Gaeta, Federico C. A., Lehman de Gaeta, Laura S., Kogan, Timothy P., Or, Yat Sun, Foster, Carolyn, Czarniecki, Michael

Journal:

Journal of Medicinal Chemistry

Year:

1990

Language:

english

File:

PDF, 1.29 MB

english, 1990

22

Cysteine alkylation in unprotected peptides: synthesis of a carbavasopressin analog by intramolecular cysteine alkylation

Or, Yat Sun, Clark, Richard F., Luly, Jay R.

Journal:

Journal of Organic Chemistry

Year:

1991

Language:

english

File:

PDF, 553 KB

english, 1991

23

Synthesis and Biological Evaluation of Novel Cyclosporin A Analogues: Potential Soft Drugs for the Treatment of Autoimmune Diseases

Lazarova, Tsvetelina, Chen, Jason S., Hamann, Blake, Kang, Jane M., Homuth-Trombino, Daniela, Han, Feng, Hoffmann, Ethan, McClure, Christopher, Eckstein, Jens, Or, Yat Sun

Journal:

Journal of Medicinal Chemistry

Year:

2003

Language:

english

File:

PDF, 42 KB

english, 2003

24

Neither the retinal ring nor the ring double bond is required for proton pumping in bacteriorhodopsin: acyclic retinal bacterioopsin analogs

Crouch, Rosalie K., Or, Yat Sun, Ghent, Shawn, Chang, Chung Ho, Govindjee, Rajni, Ebrey, Thomas G., Callender, Robert H., Pande, Ajay

Journal:

Journal of the American Chemical Society

Year:

1984

Language:

english

File:

PDF, 391 KB

english, 1984

25

Improvements in the minimum binding sequence of C5a: examination of His-67

Or, Yat Sun, Clark, Richard F., Lane, Benjamin, Mollison, Karl W., Carter, George W., Luly, Jay R.

Journal:

Journal of Medicinal Chemistry

Year:

1992

Language:

english

File:

PDF, 671 KB

english, 1992

26

Synthesis of 2-Fluoro-6- O -propargyl-11,12-carbamate Ketolides. A Novel Class of Antibiotics

Phan, Ly T., Clark, Richard F., Rupp, Michael, Or, Yat Sun, Chu, Daniel T. W., Ma, Zhenkun

Journal:

Organic Letters

Year:

2000

Language:

english

File:

PDF, 77 KB

english, 2000

27

Additions and Corrections - Pentaprismane

Eaton, Philip, Or, Yat, Branca, Stephen

Journal:

Journal of the American Chemical Society

Year:

1981

Language:

english

File:

PDF, 126 KB

english, 1981

28

Retention of Immunosuppressant Activity in an Ascomycin Analogue Lacking a Hydrogen-Bonding Interaction with FKBP12

Wiedeman, Paul E., Fesik, Stephen W., Petros, Andrew M., Nettesheim, David G., Mollison, Karl W., Lane, Benjamin C., Or, Yat Sun, Luly, Jay R.

Journal:

Journal of Medicinal Chemistry

Year:

1999

Language:

english

File:

PDF, 99 KB

english, 1999

29

The effect of variation of retinal polyene side-chain length on formation and function of bacteriorhodopsin analog pigments

Zingoni, Jesmael, Or, Yat Sun, Crouch, Rosalie K., Chang, Chung Ho, Govindjee, Rajni, Ebrey, Thomas G.

Journal:

Year:

1986

Language:

english

File:

PDF, 740 KB

english, 1986

30

32-Ascomycinyloxyacetic Acid Derived Immunosuppressants. Independence of Immunophilin Binding and Immunosuppressive Potency

Wagner, Rolf, Rhoades, Teresa A., Or, Yat Sun, Lane, Benjamin C., Hsieh, Gin, Mollison, Karl W., Luly, Jay R.

Journal:

Journal of Medicinal Chemistry

Year:

1998

Language:

english

File:

PDF, 220 KB

english, 1998

31

An Efficient Large-Scale Synthesis of EDP-420, a First-in-Class Bridged Bicyclic Macrolide (BBM) Antibiotic Drug Candidate

Xu, Guoyou, Tang, Datong, Gai, Yonghua, Wang, Guoqiang, Kim, Heejin, Chen, Zhigang, Phan, Ly T., Or, Yat Sun, Wang, Zhe

Journal:

Organic Process Research & Development

Year:

2010

Language:

english

File:

PDF, 647 KB

english, 2010

32

Initial studies on the synthesis of the antitumour agent CC-1065: 3,4-disubstituted pyrroles and 3,3?-bipyrroles

Magnus, Philip, Or, Yat-Sun

Journal:

Journal of the Chemical Society Chemical Communications

Year:

1983

Language:

english

File:

PDF, 125 KB

english, 1983

33

A rhodopsin pigment containing a spin-labeled retinal

Renk, Geoffrey E., Or, Yat Sun, Crouch, Rosalie K.

Journal:

Journal of the American Chemical Society

Year:

1987

Language:

english

File:

PDF, 717 KB

english, 1987

34

Induction of Ribosome Methylation in MLS-Resistant Streptococcus pneumoniae by Macrolides and Ketolides

ZHONG, PING, CAO, ZHENSHENG, HAMMOND, RACHEL, CHEN, YAN, BEYER, JILL, SHORTRIDGE, VIRGINIA D., PHAN, L.Y., PRATT, STEVEN, CAPOBIANCO, JOHN, REICH, KARL A., FLAMM, ROBERT K., OR, YAT-SUN, KATZ, LEONARD

Journal:

Microbial Drug Resistance

Year:

1999

Language:

english

File:

PDF, 2.33 MB

english, 1999

35

Preclinical and Clinical Resistance Profile of EDP-239, a Novel HCV NS5A Inhibitor

Owens, Christopher M., Brasher, Bradley B., Polemeropoulos, Alex, Rhodin, Michael H. J., McAllister, Nicole, Wong, Kelly A., Jones, Christopher T., Jiang, Lijuan, Lin, Kai, Or, Yat Sun

Journal:

Antimicrobial Agents and Chemotherapy

Year:

2016

Language:

english

File:

PDF, 1.03 MB

english, 2016

36

3-Keto-11,12-carbazate Derivatives of 6-0-Methylerythromycin A Synthesis and In Vitro Activity.

GRIESGRABER, GEORGE, SUN OR, YAT, CHU, DANIEL T. W., NILIUS, ANGELA M., JOHNSON, PAULINE M., FLAMM, ROBERT K., HENRY, RODGER F., PLATTNER, JACOB J.

Journal:

The Journal of Antibiotics

Year:

1996

Language:

english

File:

PDF, 1.03 MB

english, 1996

37

A Novel Farnesoid X Receptor (FXR) Agonist, EDP-305, Reduces Fibrosis Progression in Animal Models of Hepatobiliary Injury

Erstad, Derek J., Farrar, Christian T., Masia, Ricard, Santos Ferreira, Diego Dos, Choi, Ji-Kyung, Ghoshal, Sarani, Rotile, Nicholas, Li, Yang, Chau, Mary, Tanabe, Kenneth K., Or, Yat Sun, Caravan, Pe

Journal:

Gastroenterology

Year:

2017

Language:

english

File:

PDF, 651 KB

english, 2017

38

Su1500 - EDP-305 Favorably Regulates Lipoprotein Mechanism In Vitro

Chau, Mary, Roqueta-Rivera, Manuel, Garlick, Kelsey, Li, Yang, Shang, Jian, Or, Yat Sun, Jiang, Li-Juan

Journal:

Gastroenterology

Year:

2018

Language:

english

File:

PDF, 148 KB

english, 2018

39

Su1498 - A Highly Selective and Potent Farnesoid X Receptor (FXR) Agonist EDP-305 Reduces Liver Steatosis, Ballooning, and Non-Alcoholic Fatty Liver Disease Activity (NAS) in two Murine Models of Non-Alcoholic Steatohepatitis (NASH)

Jiang, Li-Juan, Chau, Mary, Li, Yang, Or, Yat Sun

Journal:

Gastroenterology

Year:

2018

Language:

english

File:

PDF, 148 KB

english, 2018

40

Su1502 - EDP-305, a Selective Farnesoid X Receptor Agonist, Exhibits Excellent Potency In Vitro and In Vivo and Anti-Fibrotic Effect In Vitro

Li, Yang, Chau, Mary, Or, Yat Sun, Jiang, Li-Juan

Journal:

Gastroenterology

Year:

2018

Language:

english

File:

PDF, 148 KB

english, 2018

41

FRI-191-EDP-514, a novel HBV core inhibitor with potent antiviral activity both in vitro and in vivo

Vaine, Michael, Dellisola, Victor, Clugston, Susan, Cao, Hui, Gao, Xuri, Kass, Jorden, Li, Wei, Peng, Xiaowen, Qiu, Yao-Ling, Jiang, Lijuan, Daniels, Kellye, Or, Yat Sun, Goodwin, Bryan, Lin, Kai

Journal:

Journal of Hepatology

Year:

2019

Language:

english

File:

PDF, 395 KB

english, 2019

42

FRI-340-In vivo effects of a novel inhibitor of apoptosis signal-regulating kinase 1 in mouse models of liver injury and metabolic disease

Roqueta-Rivera, Manuel, Chau, Mary, Wang, Guoqiang, Garlick, Kelsey, Ramachandran, Bindu, Fyfe, Susanne, Hoang, Khanh, Or, Yat Sun, Goodwin, Bryan

Journal:

Journal of Hepatology

Year:

2019

Language:

english

File:

PDF, 140 KB

english, 2019

43

FRI-340-In vivo effects of a novel inhibitor of apoptosis signal-regulating kinase 1 in mouse models of liver injury and metabolic disease

Roqueta-Rivera, Manuel, Chau, Mary, Wang, Guoqiang, Garlick, Kelsey, Ramachandran, Bindu, Fyfe, Susanne, Hoang, Khanh, Or, Yat Sun, Goodwin, Bryan

Journal:

Journal of Hepatology

Year:

2019

File:

PDF, 140 KB

2019

44

THU-084-A comparative study of anti-Fibrotic therapeutics using aptamer-based quantitative proteomics in a rat model of non-alcoholic steatohepatitis cirrhosis

Krishnan, Smitha, Goshal, Sarani, Dillon, Simon, Masia, Ricard, Ferreira, Diego, Caravan, Peter, Li, Yang, Wang, Guoqiang, Or, Yat Sun, Jiang, Lijuan, Tanabe, Kenneth K., Libermann, Towia, Fuchs, Brya

Journal:

Journal of Hepatology

Year:

2019

Language:

english

File:

PDF, 440 KB

english, 2019

45

Usability Testing for Smart IV Pumps Through Simulation-based Evaluation

Chen, Jiayin, Liu, Kaifeng, Chan, Foon-yee, Xie, Zhenzhen, Lam, Philip, Liu, Yat-wo, So, Hing-yu, Ka-lun Or, Calvin

Journal:

Proceedings of the Human Factors and Ergonomics Society Annual Meeting

Year:

2019

Language:

english

File:

PDF, 2.71 MB

english, 2019

46

PHOX2B mutations in three Chinese patients with congenital central hypoventilation syndrome

Siu-Fong, Or June, Ming-for, Tong Tony, Fai-Man, Lo Ivan, Chi-Wai, Law, Ting-Yat, Miu, Delphine, Trochet, Tak-Sum, Lam Stephen

Journal:

Chinese Medical Journal

Year:

2006

File:

PDF, 985 KB

2006

47

Usability Testing for Smart IV Pumps Through Simulation-based Evaluation

Chen, Jiayin, Liu, Kaifeng, Chan, Foon-yee, Xie, Zhenzhen, Lam, Philip, Liu, Yat-wo, So, Hing-yu, Ka-lun Or, Calvin

Journal:

Proceedings of the Human Factors and Ergonomics Society Annual Meeting

Year:

2019

File:

PDF, 2.71 MB

2019

48

A novel nonâbile acid FXR agonist EDPâ305 potently suppresses liver injury and fibrosis without worsening of ductular reaction

An, Ping, Wei, Guangyan, Huang, Pinzhu, Li, Wenda, Qi, Xiaolong, Lin, Yi, Vaid, Kahini A., Wang, Jun, Zhang, Shucha, Li, Yang, Or, Yat Sun, Jiang, LiâJuan, Popov, Yury V.

Journal:

Liver International

Year:

2020

File:

PDF, 18.71 MB

2020

49

P44 - Tissue distribution of EDP-305, a highly selective and potent farnesoid X receptor (FXR) agonist, in preclinical species

Huang, Meng, Jiang, Li-Juan, Dai, Peng, Ronsheim, Matthrew, Or, Yat Sun

Journal:

Drug Metabolism and Pharmacokinetics

Year:

2020

File:

PDF, 46 KB

2020

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